Abstract
A sensitive and specific method was developed and validated for the determination
of moxifloxacin in plasma using HPLC. The effect of diclofenac (12.5, 25, 50 mg/kg)
on the pharmacokinetics of orally administered moxifloxacin (40 mg/kg) in rats was
investigated. Pharmacokinetic parameters of moxifloxacin were determined in rats following
oral administration to rats in the presence and absence of diclofenac. The coadministration
of the 2 drugs resulted in 10~29.5% decrease of the AUC and a 24.7~34% decrease of
t1/2 for moxifloxacin; Tmax for moxifloxacin was 1.41~1.9-fold higher than that after the administration of moxifloxacin
alone; Cmax for moxifloxacin decreased by 20.5~49%, as compared to that after the administration
of moxifloxacin alone. Consequently, moxifloxacin and diclofenac should be monitored
closely for potential drug interactions.
Key words
moxifloxacin - diclofenac - pharmacokinetics - HPLC
